Malaria is a protozoan infection, an infection caused by a single celled parasite. Trump's miracle drug hydroxychloroquine should have no effect at all on a virus. You don't crack a coconut with a potato peeler.
Covid is not a Virus at all. It's a protozoan infection. Probably Pneumocystis pneumonia if I had to guess. It ticks all the boxes.
Read the description at the CDC website. Kids don't get it. It hits people with depressed immune systems hard. All the symptoms are the same. It's spread person-to-person through the air. It infects 20% of people in most Western Countries at any given time, though most never develop it. It has a long incubation period.
Tell me that's not exactly the description of Covid 19.
Yes, 5G is weakening us so that we get sick from a protozoan infection that makes no healthy person sick. An infection every westerner gets in his lifetime at least once and probably carries it for years.
Jonathan Myers
Bottom line: If hydroxychloroquine is indeed working... it's not a virus causing Covid..
Justin Martinez
Just like how can alcohol get you drunk AND be an antiseptic it cant be both
William Thomas
Antibiotics kill bacteria, they don't work on viral infections. Antiviral drugs don't work for bacterial infections. Unless this is the freak exception that they just discovered 75 years after it was first formulated.
>You don't crack a coconut with a potato peeler. Maybe you don't, ya poof.
Aaron Miller
Reading is fundamental.SARS papers 03- malaria drug HC used to treat lower respiratory infection. In fact,it is one of the few drugs powerful enough to treat these types of deep lung infections, caused when mucus is trapped there and bacteria builds. Propaganda for dummies.
Noah Campbell
Just like Hydroxychloroquine CANNOT work against inflammatory conditions. Oh wait, it does.
Xavier Ortiz
Like I told you. It will be the only one we know of that works on both viruses and bacteria. Or Covid is not a virus. Which one do you think is more likely?
Matthew White
Wasn't there a thing that covid causes iron displacement in the blood cells?
Maybe the zinc is sort of an alternative to the iron loss
meh, there is all kinds of meds that work for all kinds of shit and they don't know why. Paracetomol is one of them. they got no fucking idea how it works, but it is the most common pain reliever used worldwide. fucking black and white autismo leaf.
Nathaniel Cooper
Or those people were already iron deficient before they got sick. Who knows. A link to potassium deficiency has also been found. But it isn't caused by the, "virus." it's a contributing factor that existed before illness.
Henry Campbell
Why do you leftie fuckwits call it "Trump's drug"? You dumb shits probably think he cooked this up in his own little lab, don't you?
Dominic Ortiz
I am assuming others have shown you your error by now but becaseu i have no desire to read through your blithering dopiness I will just point out.
HCQ doesn't work on the fucking microbe it works on the fucking RED BLOOD CELLS
Sure, it's possible. Anything is possible. But working off what we know about antiviral, antibacterial drugs, this will be the first one found to work on both types. Highly unlikely.
It would be a boon for mankind if it did though. If it works on this virus, it might work on others. Believe me when I tell you, I'm pulling for you to be right. But I know that's highly unlikely.
Bentley Evans
it's because of 5G boyos, pack it up, it's over
Jose Collins
>Pneumocystis pneumonia (PCP) is a serious infection caused by the fungus Pneumocystis jirovecii. >It's not a virus it's a protozoa that infects humans with a fungus
Yup, another possible cause. One that something 75^ of the Western World is already infected with.
Matthew Cooper
It doesn't work on bacteria, shart-brain. Malaria is a parasite.
Adrian Ward
When these drugs are designed, they are designed to be specific to their target protein as much as possible. However, the chemists do not do any binding assays to all other known proteins in all known cells because that would take too much time. So what you get is that some compounds have multiple uses.
Juan Fisher
Wrong. It kills the parasite. At least that's what medical science thinks it does.
Lincoln Perry
You guys are way out of your league talking like you know how complex molecular biology and pharmacology works. >You don't crack a coconut with a potato peeler There is a drug called Amantadine that was created to treat Influenza A, and it does so well if used appropriately. It just so happens, it is also used as a treatment for Parkinson's Disease. The pathogenesis and pathophysiology of Parkinson's and Influenza A are so wildly different, and yet you can treat them with the same drug. That's cracking a coconut with a potato peeler. I'm not saying Trump is right - he has probably as little clue as you do, but for you to say he is wrong is just as blind and foolish. Maybe there is empiric value in administering Hydroxychloroquine. I'm sure you wouldn't have that data available to you at the time of this post.
Jackson Hernandez
artemisinin-based combination therapies (ACTs) P ACT
It kills the parasite by interfereing with heme. This could also be a way in which it interferes with the virus destroying red blood cells, if that is what they do. It also, by chance, alters the pH of the ACE2 receptor of the patient's cell membranes. This receptor is what the virus uses to get in, so the virus is inhibited by this.
William Murphy
The X-rays are why they think it's a virus. Typically viral pneumonia manifests over the entire lung. While bacterial pneumonia is concentrated in one or a couple lobes.
The type I suggested (Pneumocystis pneumonia) looks viral in an X-ray. That's how it could be mistaken for one. Where other types could not.
Noah Adams
Kek the joke here is mycin drugs like azithromycin are actually used to treat bacterial infections rather than viral infections. This is why it's a combination of hydroxychloroquine and azithromycin. Azithromycin inhibits the creation of proteins in a bacterial cell which stops the cell from doing metabolism and killing it. The drug can't get through the protein coat of a virus so hydroxychloroquine is used to create a pore to allow azithromycin to enter capsid and disable the virus's ribosomes.
Quinine, Chloroquine, and Hydroxychloroquine interact with the body in several complex ways. One of these interactions is a suppression of immune response, reducing inflammation. Inflammation of the lungs is one of the primary causes of death in coronavirus patients.
Ryan Parker
Viruses don't have ribosomes, genius.
Hunter White
How many times do I have to say it. Viral and bacterial drugs do not cross over. Parkinson's is not caused by a bacteria, that we know of.
Yes asprin can relieve a pain in your foot and a headache. Antiviral drugs do nothing against single celled organisms.
Asher Butler
You are on the right track for sure don't let the thread die or start another if it gets deleted.
Jose Jenkins
If that's the case, they'll just get sick again after the drug wears off. The "virus," is still there, the drug is not.
And there is some indication that might be happening in some people. The re-infection, if it exists. Or does that poor bastard just die of the existing condition he already had?
Dominic Stewart
Compounds can hve multiple uses because when they are developed, they do not do testing that makes sure they do not bind or interact with every other known protein. They only care about the specificity of the compound toward their target. So you can have drugs that normally treat viruses but can also treat bacterial infection mainly because they might share some pathway.
Leo James
1. I am demonstrating that a drug designed to treat a specific pathogen can work on a totally different pathology. I can even demonstrate another one: Metronidazole, a drug that can treat single celled bacteria like C. diff or it can treat a protozoa like Giardia lamblia. It is well within the realm of possibility that a antimicrobe drug can treat a viral infection.
2. Hydroxychloroquine or some antibiotic could improve the prognosis of a patient without actually attacking/killing the pathogen of interest. If it improves lung function or otherwise improves mortality while the body naturally fights off the virus, it is a drug of interest with valid clinical applications in the treatment of this virus.
You are so arrogant and know so little, it is embarrassing. You should just admit that we don't know yet if Hydroxychloroquine has empirical value. You can maintain your skepticism, but don't act like you KNOW because you have a high school understanding of microbiology/virology.
Oliver Johnson
Buying time for the immune system to fight the virus is a better option than just letting patients die of inflammation. It's not a silver bullet but it's better than nothing.
>diff or it can treat a protozoa like Giardia lamblia
Both are single celled organisms. It would not surprise me in the least that Metronidazole might work on both. Neither of those are viruses.
I didn't say it was impossible. I said it was highly unlikely given that we know of no other drug that treats both. This would be a first. For some reason never noticed in 75 years of Hydroxychloroquine use, until now.
Do you really buy that?
Jayden Gomez
You tell me faggot.
Adam Barnes
Sure there is a covid virus around, probly lots of them. What is killing the cult members is something tied to the blood they are using. That's why at the press conferences they don't seem worried about catching it themselves.
Nathan Foster
Don't you think Raoult knows this shit ? You dumb niggers with your "it can't work, it's not on the leaflet, case closed".
Logan White
>archive.is/ONUmi I didn't read all that coz I'm lazy but I agree with you. Cloroquine is an Ionophore and Zinc is an ion. Ions cannot penetrate cell membranes by themselves. This means that Zinc can't get into the cell to stop the RNA replicase unless there is an entryway in. That's what Cloroquine/Hydroxycloroquine does in this circumstance.
John Butler
Somebody out there knows Covid19 isn't a virus. That's why he/she proposed Hydroxychloroquine in the first place.
Find out who that person is and email them. Ask them why he/she suggested using an antiparasite drug for use against a virus. See what that person tells you.
I bet it's the same thing I just told you.
Jordan Wright
>Bottom line: If hydroxychloroquine is indeed working... it's not a virus causing Covid..
He's not arguing in good faith. He's here to muddy the water and cause confusion. China needs to go home.
Grayson Moore
We have data that shows giving a patient antibiotics when they have a viral infection has empiric value. Again, this is because it may improve the patient outcome, because it prevented a co-infection that would have increased mortality. I wouldn't hold it against a medical layman like Trump to interpret this improved prognosis as "Hydroxychloroquine cured the virus." It is a reasonable judgement for a laymen when comparing the outcome of a patient without the antibiotic to a patient with the antibiotic in the very practical scenario I laid out above. I say all of that AND STILL it is possible that this drug DIRECTLY interacts with the virus. Yes, we don't have many drugs used in the DIRECT treatment of microbes and viruses, but we know how viruses reproduce. They must bind the outside of a cell, move into the cell, replicate its nucleic acids, synthesize proteins, reassemble, and exit the host cell. There are steps here (such as nucleic acid replication, protein synthesis, and pathogen-cell binding) that are possible to pharmacologically target for the virus AND bacteria. Not to mention that there may be ways to enhance a cell's ability to defend against invaders that is applicable to both viruses and bacteria. My point is I don't know. More importantly... YOU DON'T KNOW. So stop acting like you do.
Ian Taylor
More like airborne herpes or a Flu + AIDS thing.
Xavier Brown
...
Camden Murphy
this spreads like a virus not a parasite. I did read somewhere there was reason to think it was created originally using a bacterium as host and it uses the bacteria host DNA to replicate independent of infecting human host cells.. maybe why the Zythromycin was being found effective... if this thing has a bacteria mobile supply host it would explain its more rapid and easy proliferation maybe. Its not a parasite.
>So how does chloroquine thwart coronavirus? When a virus replicates inside a host cell, its pieces get made and processed by the host cell’s manufacturing system. A major part of this protein processing center is a compartment called the Golgi apparatus, which releases those proteins within acidic vesicles called endosomes. Endosomes then deliver this protein cargo to other places, including the cell surface. Viruses can hijack this system to process and release their babies from the host cell. In addition, SARS CoV enters a host cell through an endosome vesicle formed from the host cell’s surface membrane.
>Recall that chloroquine concentrates inside acidic cellular compartments. It can get into Plasmodium’s food vacuole, but it also concentrates inside a cell’s endosomes, which are used by viruses both when they enter and exit a host cell. Chemically, chloroquine is a weak base, sufficient to raise the pH in these compartments. As endosomes become less acidic, the proteins inside are ruined — they unfold because they are no longer at the correct pH. What this means for coronavirus is that its viral proteins are rendered nonfunctional because chloroquine changed the pH of the endosomes carrying them.
>In addition to ruining the viral invader’s proteins, chloroquine can distort the shape of proteins called cytokines, which can reside in the endosomes of immune cells that fight infection. Sometimes, the immune system gets too excited and creates what is called a “cytokine storm,” which has been a major complication of COVID-19. By quelling this cytokine storm, chloroquine provides a dual advantage in helping the body combat coronavirus infection.
En français ? Parce que non, je ne parle pas assez l'anglais pour te faire un cours de médecine. youtube.com/watch?v=SfiUlVpqHfE
Levi Williams
The highly politicized debate about the use of chloroquine and hydroxychloroquine, two antimalarial drugs, to treat COVID-19 has reached an extreme in France, where two small trials purporting to show potential benefit were done. French physicians have come under enormous pressure from desperate patients to prescribe hydroxychloroquine, despite scant evidence that it works, and 460,000 people have already signed a petition to make it more widely available. Leading the advocacy is a controversial and politically well-connected figure, microbiologist Didier Raoult.
Adam Garcia
>Canadian education It's not posited it's a direct antiviral. It's a cellular inhibitor.
I'm french, everyone knows him here. If you coof, you jump in your car and drive straight to his lab. The only one who test and treat everybody, for free. No bullshit. All those people are waiting to get tested, the only place in France where you can get tested.
Here, Jews, clearly, the fucking jews, are on every fucking media shitting on this guy. They are making fake studies, giving chloroquine to patients on their death bed and saying "See ? IT DOESN'T WORK !".
Leo Johnson
Possible, 5G knocking us down to where mostly harmless parasites we're all riddled with anyway can make us sick is another possibility.
But if it was 5G, we should be seeing increases in other illnesses as well. All kins of things that couldn't touch us last year should be making us sick in 2020. Maybe they are, we just haven't noticed for all the corona panic going on.
When we stars seeing people getting paper cuts and having their limbs amputated in staggering numbers, that's when we'll know.
Oliver Collins
It seems some people don't want to try to replicate the study. Using the exact dosages and the exact drug combination.
Jackson Harris
HCQ doesn't attack the virus retard. maybe you should do a basic google search before spouting your bullshit making you look like a fucking retard
Isaac Diaz
Zowwee, who would think that pneumonia and pneumonia look similar?
